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dc.creatorReales, Guillermo
dc.creatorRovaris, Diego L.
dc.creatorJacovas, Vanessa C.
dc.creatorHünemeier, Tábita
dc.creatorSandoval, José R.
dc.creatorSalazar Granara, Alcibiades
dc.creatorDemarchi, Dario
dc.creatorTarazona Santos, Eduardo
dc.creatorFelkl, Aline B.
dc.creatorSerafini, Michele A.
dc.creatorSalzano, Francisco M.
dc.creatorBisso Machado, Rafael
dc.creatorComas, David
dc.creatorPaixão Côrtes, Vanessa R.
dc.creatorBortolini, Maria Catira
dc.date2017-07
dc.date.accessioned2021-04-06T18:18:39Z
dc.date.available2021-04-06T18:18:39Z
dc.identifierReales, Guillermo; Rovaris, Diego L.; Jacovas, Vanessa C.; Hünemeier, Tábita; Sandoval, José R.; et al.; A tale of agriculturalists and hunter-gatherers: Exploring the thrifty genotype hypothesis in native South Americans; Wiley-liss, Div John Wiley & Sons Inc; American Journal Of Physical Anthropology; 163; 3; 7-2017; 591-601
dc.identifier0002-9483
dc.identifierhttp://hdl.handle.net/11336/63293
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttp://suquia.ffyh.unc.edu.ar/handle/11336/63293
dc.descriptionObjectives: To determine genetic differences between agriculturalist and hunter-gatherer southern Native American populations for selected metabolism-related markers and to test whether Neel's thrifty genotype hypothesis (TGH) could explain the genetic patterns observed in these populations. Materials and Methods: 375 Native South American individuals from 17 populations were genotyped using six markers (APOE rs429358 and rs7412; APOA2 rs5082; CD36 rs3211883; TCF7L2 rs11196205; and IGF2BP2 rs11705701). Additionally, APOE genotypes from 39 individuals were obtained from the literature. AMOVA, main effects, and gene-gene interaction tests were performed. Results: We observed differences in allele distribution patterns between agriculturalists and hunter-gatherers for some markers. For instance, between-groups component of genetic variance (FCT) for APOE rs429358 showed strong differences in allelic distributions between hunter-gatherers and agriculturalists (p = 0.00196). Gene-gene interaction analysis indicated that the APOE E4/CD36 TT and APOE E4/IGF2BP2 A carrier combinations occur at a higher frequency in hunter-gatherers, but this combination is not replicated in archaic (Neanderthal and Denisovan) and ancient (Anzick, Saqqaq, Ust-Ishim, Mal'ta) hunter-gatherer individuals. Discussion: A complex scenario explains the observed frequencies of the tested markers in hunter-gatherers. Different factors, such as pleotropic alleles, rainforest selective pressures, and population dynamics, may be collectively shaping the observed genetic patterns. We conclude that although TGH seems a plausible hypothesis to explain part of the data, other factors may be important in our tested populations.
dc.descriptionFil: Reales, Guillermo. Universidade Federal do Rio Grande do Sul; Brasil
dc.descriptionFil: Rovaris, Diego L.. Universidade Federal do Rio Grande do Sul; Brasil
dc.descriptionFil: Jacovas, Vanessa C.. Universidade Federal do Rio Grande do Sul; Brasil
dc.descriptionFil: Hünemeier, Tábita. Universidade de Sao Paulo; Brasil
dc.descriptionFil: Sandoval, José R.. Universidad de San Martín de Porres. Facultad de Medicina Humana; Perú
dc.descriptionFil: Salazar Granara, Alcibiades. Universidad de San Martín de Porres. Facultad de Medicina Humana; Perú
dc.descriptionFil: Demarchi, Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Antropología de Córdoba. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Instituto de Antropología de Córdoba; Argentina
dc.descriptionFil: Tarazona Santos, Eduardo. Universidade Federal de Minas Gerais; Brasil
dc.descriptionFil: Felkl, Aline B.. Universidade Federal do Rio Grande do Sul; Brasil
dc.descriptionFil: Serafini, Michele A.. Universidade Federal do Rio Grande do Sul; Brasil
dc.descriptionFil: Salzano, Francisco M.. Universidade Federal do Rio Grande do Sul; Brasil
dc.descriptionFil: Bisso Machado, Rafael. Universidad de la República; Uruguay
dc.descriptionFil: Comas, David. Universitat Pompeu Fabra; España
dc.descriptionFil: Paixão Côrtes, Vanessa R.. Universidade Federal da Bahia; Brasil
dc.descriptionFil: Bortolini, Maria Catira. Universidade Federal do Rio Grande do Sul; Brasil
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley-liss, Div John Wiley & Sons Inc
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1002/ajpa.23233
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajpa.23233
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subjectADAPTATION
dc.subjectAPOE
dc.subjectMODE OF SUBSISTENCE
dc.subjectPLEIOTROPY
dc.subjectOtras Ciencias Biológicas
dc.subjectCiencias Biológicas
dc.subjectCIENCIAS NATURALES Y EXACTAS
dc.subjectGenética y Herencia
dc.subjectCiencias Biológicas
dc.subjectCIENCIAS NATURALES Y EXACTAS
dc.titleA tale of agriculturalists and hunter-gatherers: Exploring the thrifty genotype hypothesis in native South Americans
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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