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NAT2 gene diversity and its evolutionary trajectory in the Americas

dc.creatorBisso Machado, R.
dc.creatorRamallo, Virginia
dc.creatorPaixão Côrtes, V. R.
dc.creatorAcuña Alonzo, V.
dc.creatorDemarchi, Dario
dc.creatorSandoval, J. R. S.
dc.creatorGranara, A. A. S.
dc.creatorSalzano, F. M.
dc.creatorHünemeier, T.
dc.creatorBortolini, M. C.
dc.date2016-11
dc.date.accessioned2021-04-06T18:18:49Z
dc.date.available2021-04-06T18:18:49Z
dc.identifierBisso Machado, R.; Ramallo, Virginia; Paixão Côrtes, V. R.; Acuña Alonzo, V.; Demarchi, Dario; et al.; NAT2 gene diversity and its evolutionary trajectory in the Americas; Macmillan Publishers; Pharmacogenomics Journal; 16; 11-2016; 559-565
dc.identifier1470-269X
dc.identifierhttp://hdl.handle.net/11336/11705
dc.identifier1473-1150
dc.identifier.urihttp://suquia.ffyh.unc.edu.ar/handle/11336/11705
dc.descriptionN-acetyltransferase 2 (NAT2) is responsible for metabolizing xenobiotics; NAT2 polymorphisms lead to three phenotypes: rapid, intermediate and slow acetylators. We aimed to investigate NAT2 diversity in Native Americans. NAT2 exon 2 was sequenced for 286 individuals from 21 populations (Native American and American Mestizos). Excluding the basal/rapid haplotype NAT2*4, the most frequent haplotypes are NAT2*5B (35.95%) in hunter-gatherers and NAT2*7B (20.61%) and NAT2*5B (19.08%) in agriculturalists that were related to the slow phenotype. A new haplotype was identified in two Amerindians. Data from the ~ 44 kb region surrounding NAT2 in 819 individuals from Africa, East-Asia, Europe and America were used in additional analyses. No significant differences in the acetylator NAT2 haplotype and phenotype distributions were found between Native American populations practicing farming and/or herding and those practicing hunting and gathering, probably because of the absence or weakness of selection pressures and presence of demographic and random processes preventing detection of any selection signal.
dc.descriptionFil: Bisso Machado, R.. Universidade Federal do Rio Grande do Sul; Brasil
dc.descriptionFil: Ramallo, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.descriptionFil: Paixão Côrtes, V. R.. Universidade Federal do Rio Grande do Sul; Brasil
dc.descriptionFil: Acuña Alonzo, V.. Escuela Nacional de Antropología e Historia; México
dc.descriptionFil: Demarchi, Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto de Antropología de Córdoba; Argentina. Universidad Nacional de Córdoba; Argentina
dc.descriptionFil: Sandoval, J. R. S.. Universidad de San Martin de Porres; Perú
dc.descriptionFil: Granara, A. A. S.. Universidad de San Martin de Porres; Perú
dc.descriptionFil: Salzano, F. M.. Universidade Federal do Rio Grande do Sul; Brasil
dc.descriptionFil: Hünemeier, T.. Universidade de Sao Paulo; Brasil
dc.descriptionFil: Bortolini, M. C.. Universidade Federal do Rio Grande do Sul; Brasil
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherMacmillan Publishers
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1038/tpj.2015.72
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.nature.com/tpj/journal/v16/n6/full/tpj201572a.html
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subjectN-ACETYLTRANSFERASE 2
dc.subjectAMERINDIANS
dc.subjectHUNTER
dc.subjectAGRICULTURALISTS
dc.subjectGATHERERS
dc.subjectGenética y Herencia
dc.subjectCiencias Biológicas
dc.subjectCIENCIAS NATURALES Y EXACTAS
dc.titleNAT2 gene diversity and its evolutionary trajectory in the Americas
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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